The Agency for Healthcare Research and Quality’s (AHRQ’s) requested comments the challenges and opportunities presented by learning health systems, which the National Academy of Medicine defines as a system “designed to generate and apply the best evidence for the collaborative healthcare choices of each patient and provider; to drive the process of discovery as a natural outgrowth of patient care; and to ensure innovation, quality, safety, and value in health care.” As AHRQ works to advance the development of learning health systems, it should prioritize eliminating data poverty to increase the effectiveness of the systems as a whole and ensure that all communities can reap the benefits.